CBS C699T
rs234706wt
100% modeled activity
het
85% modeled activity
hom
70% modeled activity
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Transsulfuration
CBS Transsulfuration Terrain
Sulfur routing, glutathione precursor pressure, and transsulfuration uncertainty.
Evidence quality visible
No dosing or treatment advice
Terrain context linked
What The Enzyme Does
CBS is represented as a transsulfuration enzyme that routes sulfur metabolism toward glutathione precursor capacity in the Phase 1A seed graph.
- Gene
- Cystathionine beta-synthase
- External IDs
- HGNC:HGNC:1550, NCBI_GENE:875
What The Variants Change
The current genotype control covers CBS C699T only. Other CBS variants remain roadmap items until curated records are added.
Downstream Consequences
- Reduced modeled CBS activity lowers relative support for the reduced-glutathione pool.
- CBS-related interpretations are currently mechanistic and should be treated as uncertainty-labeled pathway context.
- The current model does not claim sulfite, ammonia, or symptom prediction.
Cross-System Connections
CBS routes sulfur toward glutathione synthesis
CATALYZESCBS to gsh; qualitative coefficient 0.6
Connected pools: Reduced glutathione