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Production terrain atlas

Metabolic Terrain Console

Toggle pathway variants, inspect qualitative flux direction and magnitude across the methylation cascade and SAMe hub, and test the governed evidence prompt interface. Outputs are relative direction and magnitude only.

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Variant Controls

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Shareable links encode curated variant states only.

Methylation cycle

MTHFR C677T (rs1801133)
AHCY rs819147 (rs819147)

SAMe consumers

COMT Val158Met (rs4680)
PEMT rs12325817 (rs12325817)
HNMT Thr105Ile (rs11558538)

Transsulfuration

CBS C699T (rs234706)

Glutathione / NADPH

NADK redox-capacity marker (mbq-nadk-redox-capacity-marker)
G6PD rs1050828 (rs1050828)

Condition Deep Dives

Terrain Map

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Map controls
MTHFR supports 5-MTHF production (→ 1.00x)→ 1.00xReduced remethylation pressure raises Hcy risk (→ 1.00x)→ 1.00xCBS routes sulfur toward glutathione synthesis (→ 0.60x)→ 0.60xCOMT consumes methyl donors (→ 0.35x)→ 0.35xAHCY clears SAH pressure from methylation turnover (→ 0.42x)→ 0.42xNADK supports NADPH pool capacity (→ 0.55x)→ 0.55xG6PD supports oxidative PPP NADPH generation (→ 0.72x)→ 0.72xMTR consumes 5-MTHF to remethylate homocysteine (→ 0.30x)→ 0.30xMTR remethylates homocysteine toward methionine (→ 0.50x)→ 0.50xMTR produces methionine from remethylation (→ 0.60x)→ 0.60xMAT1A consumes methionine to synthesize SAMe (→ 0.45x)→ 0.45xMAT1A produces SAMe, the universal methyl donor (→ 0.70x)→ 0.70xPEMT consumes SAMe for phosphatidylcholine synthesis (→ 0.40x)→ 0.40xHNMT consumes SAMe to methylate histamine (→ 0.25x)→ 0.25x

Selected Node

MTHFR

gene

methylation cycle

Clinical-study evidence

Moderate uncertainty — observational/clinical

Evidence refs: ev-mthfr-kinetics

Qualitative Flux State

5-MTHF

1.00x

stable

Homocysteine

1.00x

stable

SAMe

1.00x

stable

SAH

1.00x

stable

NADPH

1.00x

stable

Reduced glutathione

1.00x

stable

Methionine

1.00x

stable

Evidence Prompt Gate

MTHFR C677T residual activity and folate-cycle effect: clinical_study

CBS transsulfuration routing and glutathione precursor pressure: mechanistic_inference

COMT methyl donor demand and SAMe competition: mechanistic_inference

AHCY and SAH pressure in methylation turnover: mechanistic_inference

NADK contribution to NADPH pool capacity: mechanistic_inference

G6PD oxidative pentose phosphate pathway NADPH generation: clinical_study

MTR-dependent homocysteine remethylation to methionine: mechanistic_inference

MAT1A methionine adenosyltransferase SAMe synthesis: mechanistic_inference

PEMT methyl-donor demand on the SAMe pool: mechanistic_inference

HNMT histamine methylation SAMe demand: mechanistic_inference