COMT Val158Met
rs4680wt
100% modeled activity
het
72% modeled activity
hom
45% modeled activity
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SAMe consumer
COMT Val158Met Terrain
SAMe demand, methyl-donor competition, and same-consumer pathway context.
Evidence quality visible
No dosing or treatment advice
Terrain context linked
What The Enzyme Does
COMT is represented as a SAMe-consuming enzyme. The current terrain model tracks how COMT activity changes relative methyl-donor demand.
- Gene
- Catechol-O-methyltransferase
- External IDs
- HGNC:HGNC:2228, NCBI_GENE:1312
What The Variants Change
The Phase 1A genotype control covers COMT Val158Met with qualitative residual-activity states.
Downstream Consequences
- Lower modeled COMT activity reduces relative SAMe consumption pressure.
- COMT is interpreted as one consumer in a wider methylation context, not a stand-alone behavioral prediction.
- The current model does not infer medication, supplement, or psychiatric treatment recommendations.
Cross-System Connections
COMT consumes methyl donors
PRODUCES_CONSUMESCOMT to same; qualitative coefficient -0.35
Connected pools: SAMe